[HTML][HTML] Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1

L Morel, M Regan, H Higashimori, SK Ng… - Journal of Biological …, 2013 - ASBMB
Perisynaptic astrocytes express important glutamate transporters, especially excitatory
amino acid transporter 2 (EAAT2, rodent analog GLT1) to regulate extracellular glutamate
levels and modulate synaptic activation. In this study, we investigated an exciting new
pathway, the exosome-mediated transfer of microRNA (in particular, miR-124a), in neuron-to-
astrocyte signaling. Exosomes isolated from neuron-conditioned medium contain abundant
microRNAs and small RNAs. These exosomes can be directly internalized into astrocytes …