Accumulating evidence shows that several cell types have the capacity to secrete
membrane proteins by incorporating them into exosomes, which are small lipid vesicles
derived from the intralumenal membranes of multivesicular bodies (MVBs) of the endocytic
pathway. Exosomes are expelled in the extracellular space upon fusion of the MVB with the
plasma membrane. Exosomal release is a way of secreting membrane proteins meant to be
discarded, or to be passed on to other cells. Here, we demonstrate, using primary cortical …