[HTML][HTML] Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice

C Coffinier, HJ Jung, Z Li, C Nobumori, UJ Yun… - Journal of biological …, 2010 - ASBMB
Lamin A, a key component of the nuclear lamina, is generated from prelamin A by four post-
translational processing steps: farnesylation, endoproteolytic release of the last three amino
acids of the protein, methylation of the C-terminal farnesylcysteine, and finally,
endoproteolytic release of the last 15 amino acids of the protein (including the
farnesylcysteine methyl ester). The last cleavage step, mediated by ZMPSTE24, releases
mature lamin A. This processing scheme has been conserved through vertebrate evolution …