Epidermal growth factor receptor (EGFR) and squamous cell carcinoma of the skin: molecular bases for EGFR-targeted therapy
P Uribe, S Gonzalez - Pathology-Research and Practice, 2011 - Elsevier
Cutaneous squamous cell carcinoma (SCC) ranks second in the frequency of all skin
tumors. Its incidence has risen significantly due to an increased sun exposure and the
number of immunocompromised patients. It has a well-defined progression with known
precursor lesions called actinic keratosis. The degree of cellular differentiation, tumor
thickness, location, and other features has prognostic value. It has a better prognosis than
mucosal SCC of the head and neck, also called head and neck squamous cell carcinoma …
tumors. Its incidence has risen significantly due to an increased sun exposure and the
number of immunocompromised patients. It has a well-defined progression with known
precursor lesions called actinic keratosis. The degree of cellular differentiation, tumor
thickness, location, and other features has prognostic value. It has a better prognosis than
mucosal SCC of the head and neck, also called head and neck squamous cell carcinoma …