[PDF][PDF] Sleuthing the source of regeneration by MSCs

M Pittenger - Cell stem cell, 2009 - cell.com
M Pittenger
Cell stem cell, 2009cell.com
Sleuthing the Source of Regeneration by MSCs Page 1 new hair shaft becomes prominently
gray. Consistent with an effect of genotoxic stress on the MSCs, mice with a mutation in the
DNA damage checkpoint kinase ATM (mutated in ataxia-telangiectasia) showed graying at a
lower dose of ionizing radiation and a significant increase in the appearance of EPMs within the
niche. A particularly striking finding in the study is that, despite these profound effects of DNA
damage on MSCs, the authors find no evidence of apoptosis or senescence in these failing …
Mesenchymal stem cells (MSCs) can differentiate into useful cell types and also have the ability to modulate inflammation. In this issue of Cell Stem Cell, Lee et al. (2009) investigate the production of the soluble inflammation inhibitor TSG-6 by MSCs.
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