[HTML][HTML] Overexpression of the c-myc oncogene inhibits nonsense-mediated RNA decay in B lymphocytes
D Wang, J Wengrod, LB Gardner - Journal of Biological Chemistry, 2011 - ASBMB
The Myc transcription factor plays a vital role in both normal cellular physiology and in many
human cancers. We have recently demonstrated that nonsense-mediated RNA decay
(NMD), a mechanism that rapidly degrades select mRNAs, is inhibited by the stress-induced
phosphorylation of translation initiation factor eIF2α, and this inhibition stabilizes many
transcripts necessary for tumorigenesis. Here, we demonstrate that NMD is inhibited by high
Myc expression. We show that the phosphorylation of eIF2α, likely due to the ability of Myc to …
human cancers. We have recently demonstrated that nonsense-mediated RNA decay
(NMD), a mechanism that rapidly degrades select mRNAs, is inhibited by the stress-induced
phosphorylation of translation initiation factor eIF2α, and this inhibition stabilizes many
transcripts necessary for tumorigenesis. Here, we demonstrate that NMD is inhibited by high
Myc expression. We show that the phosphorylation of eIF2α, likely due to the ability of Myc to …