Transduction peptides: from technology to physiology
A Joliot, A Prochiantz - Nature cell biology, 2004 - nature.com
A Joliot, A Prochiantz
Nature cell biology, 2004•nature.comDuring the past fifteen years, a variety of peptides have been characterized for their ability to
translocate into live cells. Most are efficient vectors that can internalize hydrophilic cargoes,
and so provide a valuable biological (and potentially therapeutic) tool for targeting proteins
into cells. Furthermore, translocation of cell-permeable peptides across the plasma
membrane and their subsequent access to the cytosol, even when fused to large hydrophilic
proteins, is challenging the perception of the plasma membrane as an impermeable barrier.
translocate into live cells. Most are efficient vectors that can internalize hydrophilic cargoes,
and so provide a valuable biological (and potentially therapeutic) tool for targeting proteins
into cells. Furthermore, translocation of cell-permeable peptides across the plasma
membrane and their subsequent access to the cytosol, even when fused to large hydrophilic
proteins, is challenging the perception of the plasma membrane as an impermeable barrier.
Abstract
During the past fifteen years, a variety of peptides have been characterized for their ability to translocate into live cells. Most are efficient vectors that can internalize hydrophilic cargoes, and so provide a valuable biological (and potentially therapeutic) tool for targeting proteins into cells. Furthermore, translocation of cell-permeable peptides across the plasma membrane and their subsequent access to the cytosol, even when fused to large hydrophilic proteins, is challenging the perception of the plasma membrane as an impermeable barrier.
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