Monoclonal mouse antiplatelet antibodies against a variety of platelet surface components
can activate platelets, causing platelet aggregation and secretion. The mechanism involves
binding of the Fab domain to a platelet surface antigen, and the activation occurs through an
interaction of the Fc domain with the platelet FcγRII receptor. There is almost no information
on FcγRII receptor-dependent activation of platelets by polyclonal rabbit antibodies. We
presently report that a polyclonal rabbit antibody to a platelet surface antigen, protein …