[HTML][HTML] The role of hyaluronan degradation products as innate alloimmune agonists
Dendritic cells (DCs) play a key role in initiating alloimmunity yet the substances that activate
them during the host response to transplantation remain elusive. In this study we examined
the potential roles of endogenous innate immune agonists in activating dendritic cell-
dependent alloimmunity. Using a murine in vitroculture system, we show that 135 KDa
fragments of the extracellular matrix glycosaminoglycan hyaluronan induce dendritic cell
maturation and initiate alloimmunity. Priming of alloimmunity by hyaluronan-activated DCs …
them during the host response to transplantation remain elusive. In this study we examined
the potential roles of endogenous innate immune agonists in activating dendritic cell-
dependent alloimmunity. Using a murine in vitroculture system, we show that 135 KDa
fragments of the extracellular matrix glycosaminoglycan hyaluronan induce dendritic cell
maturation and initiate alloimmunity. Priming of alloimmunity by hyaluronan-activated DCs …