Posttraining systemic administration of the histone deacetylase inhibitor sodium butyrate ameliorates aging-related memory decline in rats
GK Reolon, N Maurmann, A Werenicz… - Behavioural brain …, 2011 - Elsevier
Behavioural brain research, 2011•Elsevier
Here we show that a systemic injection of the histone deacetylase inhibitor (HDACi) sodium
butyrate (NaB) ameliorated an aging-associated deficit in object recognition memory in rats
when the injection was given immediately, but not 6 h after training. NaB had no effect in
younger rats with normal memory retention. The results indicate that HDACis can ameliorate
aging-related memory impairments by influencing the early consolidation phase of memory
formation.
butyrate (NaB) ameliorated an aging-associated deficit in object recognition memory in rats
when the injection was given immediately, but not 6 h after training. NaB had no effect in
younger rats with normal memory retention. The results indicate that HDACis can ameliorate
aging-related memory impairments by influencing the early consolidation phase of memory
formation.
Abstract
Here we show that a systemic injection of the histone deacetylase inhibitor (HDACi) sodium butyrate (NaB) ameliorated an aging-associated deficit in object recognition memory in rats when the injection was given immediately, but not 6 h after training. NaB had no effect in younger rats with normal memory retention. The results indicate that HDACis can ameliorate aging-related memory impairments by influencing the early consolidation phase of memory formation.
Elsevier