Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors
AM Hartmann, D Rujescu, T Giannakouros… - Molecular and Cellular …, 2001 - Elsevier
Tau is a microtubule-associated protein whose transcript undergoes regulated splicing in
the mammalian nervous system. Exon 10 of the gene is an alternatively spliced cassette that
is adult-specific and encodes a microtubule-binding domain. Mutations increasing the
inclusion of exon 10 result in the production of tau protein which predominantly contains four
microtubule-binding repeats and were shown to cause frontotemporal dementia and
parkinsonism linked to chromosome 17 (FTDP-17). Here we show that exon 10 usage is …
the mammalian nervous system. Exon 10 of the gene is an alternatively spliced cassette that
is adult-specific and encodes a microtubule-binding domain. Mutations increasing the
inclusion of exon 10 result in the production of tau protein which predominantly contains four
microtubule-binding repeats and were shown to cause frontotemporal dementia and
parkinsonism linked to chromosome 17 (FTDP-17). Here we show that exon 10 usage is …