Platelet-neutrophil interactions.(12S)-hydroxyeicosatetraen-1, 20-dioic acid: a new eicosanoid synthesized by unstimulated neutrophils from (12S)-20 …
AJ Marcus, LB Safier, HL Ullman, N Islam… - Journal of Biological …, 1988 - ASBMB
In the course of a cell-cell interaction, 12-HETE (12-hydroxy-5, 8, 10, 14-eicosatetraenoic
acid), the arachidonic acid lipoxygenase product released from stimulated platelets, is
metabolized by a cytochrome P-450 enzyme system in unstimulated neutrophils to 12, 20-
DiHETE (12, 20-dihydroxy-5, 8, 10, 14-eicosatetraenoic acid). This report describes time-
dependent formation of a new eicosanoid by unstimulated neutrophils exposed to 12-HETE,
which is more polar than 12, 20-DiHETE (reversed-phase high performance liquid …
acid), the arachidonic acid lipoxygenase product released from stimulated platelets, is
metabolized by a cytochrome P-450 enzyme system in unstimulated neutrophils to 12, 20-
DiHETE (12, 20-dihydroxy-5, 8, 10, 14-eicosatetraenoic acid). This report describes time-
dependent formation of a new eicosanoid by unstimulated neutrophils exposed to 12-HETE,
which is more polar than 12, 20-DiHETE (reversed-phase high performance liquid …