[HTML][HTML] cAMP-stimulated protein phosphatase 2A activity associated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibits the …
KL Dodge-Kafka, A Bauman, N Mayer… - Journal of biological …, 2010 - ASBMB
The concentration of the second messenger cAMP is tightly controlled in cells by the activity
of phosphodiesterases. We have previously described how the protein kinase A-anchoring
protein mAKAP serves as a scaffold for the cAMP-dependent protein kinase PKA and the
cAMP-specific phosphodiesterase PDE4D3 in cardiac myocytes. PKA and PDE4D3
constitute a negative feedback loop whereby PKA-catalyzed phosphorylation and activation
of PDE4D3 attenuate local cAMP levels. We now show that protein phosphatase 2A (PP2A) …
of phosphodiesterases. We have previously described how the protein kinase A-anchoring
protein mAKAP serves as a scaffold for the cAMP-dependent protein kinase PKA and the
cAMP-specific phosphodiesterase PDE4D3 in cardiac myocytes. PKA and PDE4D3
constitute a negative feedback loop whereby PKA-catalyzed phosphorylation and activation
of PDE4D3 attenuate local cAMP levels. We now show that protein phosphatase 2A (PP2A) …