[HTML][HTML] Selection of protein phosphatase 2A regulatory subunits is mediated by the C terminus of the catalytic Subunit
S Longin, K Zwaenepoel, JV Louis, S Dilworth… - Journal of Biological …, 2007 - ASBMB
Protein phosphatase 2A (PP2A) is a family of multifunctional serine/threonine phosphatases
all composed of a catalytic C, a structural A, and a regulatory B subunit. Assembly of the
complex with the appropriate B subunit forms the key to the functional specificity and
regulation of PP2A. Emerging evidence suggests a crucial role for methylation and
phosphorylation of the PP2A C subunit in this process. In this study, we show that PP2A C
subunit methylation was not absolutely required for binding the PR61/B′ and PR72/B …
all composed of a catalytic C, a structural A, and a regulatory B subunit. Assembly of the
complex with the appropriate B subunit forms the key to the functional specificity and
regulation of PP2A. Emerging evidence suggests a crucial role for methylation and
phosphorylation of the PP2A C subunit in this process. In this study, we show that PP2A C
subunit methylation was not absolutely required for binding the PR61/B′ and PR72/B …