[HTML][HTML] Designer and catalytic antibodies

RD Mayforth, J Quintáns - New England Journal of Medicine, 1990 - Mass Medical Soc
RD Mayforth, J Quintáns
New England Journal of Medicine, 1990Mass Medical Soc
A HUMAN being possesses on the order of 1 trillion (1012) B cells, capable of making more
than 10 million different antibodies. Tapping this vast resource for clinical purposes is an
important but technically challenging endeavor. The production of hybridomas makes it
feasible to manufacture large quantities of monoclonal antibodies, and in principle that
method appeared to provide the ideal way to produce a large repertoire of human
antibodies. Unfortunately, only mouse and rat myeloma cell lines have turned out to be …
A HUMAN being possesses on the order of 1 trillion (1012) B cells, capable of making more than 10 million different antibodies. Tapping this vast resource for clinical purposes is an important but technically challenging endeavor. The production of hybridomas makes it feasible to manufacture large quantities of monoclonal antibodies, and in principle that method appeared to provide the ideal way to produce a large repertoire of human antibodies. Unfortunately, only mouse and rat myeloma cell lines have turned out to be reliable fusion partners for the production of stable hybridomas. Rodent monoclonal antibodies have provided many new reagents . . .
The New England Journal Of Medicine