Studies of the mechanisms of bradykinin generation in hereditary angioedema plasma
K Joseph, TB Tuscano, AP Kaplan - Annals of Allergy, Asthma & …, 2008 - Elsevier
BACKGROUND: Factor XII–dependent bradykinin formation is thought to be responsible for
the swelling associated with the various forms of C1 inhibitor deficiency, and complement
activation is augmented during attacks of swelling. OBJECTIVES: To further elucidate the
interactions of the kinin-forming cascade that lead to complement activation during attacks of
swelling and to determine whether fibrinolysis is augmented as well. METHODS: We
compared spontaneous and kaolin-induced activation of normal plasma with the plasma of …
the swelling associated with the various forms of C1 inhibitor deficiency, and complement
activation is augmented during attacks of swelling. OBJECTIVES: To further elucidate the
interactions of the kinin-forming cascade that lead to complement activation during attacks of
swelling and to determine whether fibrinolysis is augmented as well. METHODS: We
compared spontaneous and kaolin-induced activation of normal plasma with the plasma of …