The mechanisms by which receptor tyrosine kinases (RTKs) utilize intracellular signaling
pathways to direct gene expression and cellular response remain unclear. A current
question is whether different RTKs within a single cell target similar or different sets of
genes. In this study we have used the ErbB receptor network to explore the relationship
between RTK activation and gene expression. We profiled growth factor-stimulated
signaling pathway usage and broad gene expression patterns in two human mammary …