Subcutaneous drug delivery and the role of the lymphatics

DN McLennan, CJH Porter, SA Charman - Drug Discovery Today …, 2005 - Elsevier
Subcutaneous injections are widely utilised as a delivery route for compounds with limited
oral bioavailability or as a means to modify or extend the release profile. In this review,
factors affecting absorption from the subcutaneous space are discussed with particular
emphasis on differential drug absorption into either the underlying blood or lymphatic
capillaries. Formulation and targeted delivery approaches, which utilise the subcutaneous
administration route, are reviewed with reference to associated technologies and future …