The nature of the principal type 1 interferon-producing cells in human blood
FP Siegal, N Kadowaki, M Shodell… - Science, 1999 - science.org
FP Siegal, N Kadowaki, M Shodell, PA Fitzgerald-Bocarsly, K Shah, S Ho, S Antonenko…
Science, 1999•science.orgInterferons (IFNs) are the most important cytokines in antiviral immune responses.“Natural
IFN-producing cells”(IPCs) in human blood express CD4 and major histocompatibility
complex class II proteins, but have not been isolated and further characterized because of
their rarity, rapid apoptosis, and lack of lineage markers. Purified IPCs are here shown to be
the CD4+ CD11c− type 2 dendritic cell precursors (pDC2s), which produce 200 to 1000
times more IFN than other blood cells after microbial challenge. pDC2s are thus an effector …
IFN-producing cells”(IPCs) in human blood express CD4 and major histocompatibility
complex class II proteins, but have not been isolated and further characterized because of
their rarity, rapid apoptosis, and lack of lineage markers. Purified IPCs are here shown to be
the CD4+ CD11c− type 2 dendritic cell precursors (pDC2s), which produce 200 to 1000
times more IFN than other blood cells after microbial challenge. pDC2s are thus an effector …
Interferons (IFNs) are the most important cytokines in antiviral immune responses. “Natural IFN-producing cells” (IPCs) in human blood express CD4 and major histocompatibility complex class II proteins, but have not been isolated and further characterized because of their rarity, rapid apoptosis, and lack of lineage markers. Purified IPCs are here shown to be the CD4+CD11c− type 2 dendritic cell precursors (pDC2s), which produce 200 to 1000 times more IFN than other blood cells after microbial challenge. pDC2s are thus an effector cell type of the immune system, critical for antiviral and antitumor immune responses.
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