[HTML][HTML] Ganglioside GM3 activates ERKs in human lymphocytic cells
T Garofalo, M Sorice, R Misasi, B Cinque, V Mattei… - Journal of lipid …, 2002 - ASBMB
In this study we analyzed the signaling pathway triggered by GM3 in lymphoblastoid T-cells.
In these cells, GM3 induced cPLA 2 activation, arachidonic acid release, and PKC-δ
translocation. In order to clarify the upstream molecular signals triggered by GM3, we
analyzed the activation of extracellular signal-regulated kinase (ERK) s, a downstream
effector of Ras-regulated cytoplasmic kinase cascade. Our results showed that GM3
treatment led to rapid ERK phosphorylation in lymphoblastoid T-cells, as detected by anti …
In these cells, GM3 induced cPLA 2 activation, arachidonic acid release, and PKC-δ
translocation. In order to clarify the upstream molecular signals triggered by GM3, we
analyzed the activation of extracellular signal-regulated kinase (ERK) s, a downstream
effector of Ras-regulated cytoplasmic kinase cascade. Our results showed that GM3
treatment led to rapid ERK phosphorylation in lymphoblastoid T-cells, as detected by anti …