[HTML][HTML] Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques
AP Turner, VO Shaffer, K Araki, C Martens… - American Journal of …, 2011 - Elsevier
Sirolimus is a potent antiproliferative agent used clinically to prevent renal allograft rejection.
However, little is known about the effects of maintenance immunosuppressive agents on the
immune response to potentially protective vaccines. Here we show that sirolimus
paradoxically increases the magnitude and quality of the CD8+ T-cell response to vaccinia
vaccination in nonhuman primates, fostering more robust recall responses compared to
untreated and tacrolimus-treated controls. Enhancement of both the central and effector …
However, little is known about the effects of maintenance immunosuppressive agents on the
immune response to potentially protective vaccines. Here we show that sirolimus
paradoxically increases the magnitude and quality of the CD8+ T-cell response to vaccinia
vaccination in nonhuman primates, fostering more robust recall responses compared to
untreated and tacrolimus-treated controls. Enhancement of both the central and effector …