Proteins that engage in intracellular interactions with other proteins are widely considered
among the most biologically appealing yet chemically intractable targets for drug discovery.
The critical interaction surfaces of these proteins typically lack the deep hydrophobic
involutions that enable potent, selective targeting by small organic molecules, and their
localization within the cell puts them beyond the reach of protein therapeutics. Considerable
interest has therefore arisen in next-generation targeting molecules that combine the broad …