[HTML][HTML] Loss of daylight vision in retinal degeneration: are oxidative stress and metabolic dysregulation to blame?
Retinitis pigmentosa is characterized by loss of night vision, followed by complete blindness.
Over 40 genetic loci for retinitis pigmentosa have been identified in humans, primarily
affecting photoreceptor structure and function. The availability of excellent animal models
allows for a mechanistic characterization of the disease. Metabolic dysregulation and
oxidative stress have been found to correlate with the loss of vision, particularly in cones, the
type of photoreceptors that mediate daylight and color vision. The evidence that these …
Over 40 genetic loci for retinitis pigmentosa have been identified in humans, primarily
affecting photoreceptor structure and function. The availability of excellent animal models
allows for a mechanistic characterization of the disease. Metabolic dysregulation and
oxidative stress have been found to correlate with the loss of vision, particularly in cones, the
type of photoreceptors that mediate daylight and color vision. The evidence that these …