[HTML][HTML] Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects
JR Greenfield, IS Farooqi, JM Keogh, E Henning… - The American journal of …, 2009 - Elsevier
Background Incretin hormones, such as glucagon-like peptide 1 (GLP-1) and glucose-
dependent insulinotropic polypeptide (GIP), play an important role in meal-related insulin
secretion. We previously demonstrated that glutamine is a potent stimulus of GLP-1
secretion in vitro. Objective Our objective was to determine whether glutamine increases
circulating GLP-1 and GIP concentrations in vivo and, if so, whether this is associated with
an increase in plasma insulin. Design We recruited 8 healthy normal-weight volunteers …
dependent insulinotropic polypeptide (GIP), play an important role in meal-related insulin
secretion. We previously demonstrated that glutamine is a potent stimulus of GLP-1
secretion in vitro. Objective Our objective was to determine whether glutamine increases
circulating GLP-1 and GIP concentrations in vivo and, if so, whether this is associated with
an increase in plasma insulin. Design We recruited 8 healthy normal-weight volunteers …