Prenatal processing of pro-opiomelanocortin in the brain and pituitary of mouse embryos
RA Rius, T Chikuma, YP Loh - Developmental brain research, 1991 - Elsevier
The processing of pro-opiomelanocortin (POMC) to ACTH-(adrenocorticotropin), MSH-
(melanotropin) and endorphin-related peptides was studied in mouse embryos with the
ultimate aim of determining the role of the POMC-related peptides in early development
especially in the CNS. Mouse embryos at gestational days 10.5, 11.5, 12.5 and 14.5 were
analyzed for POMC-derived peptides by SDS-PAGE, HPLC and radioimmunoassay using
antisera specific for various regions of the prohormone. At embryonic day 10.5 (E 10.5) the …
(melanotropin) and endorphin-related peptides was studied in mouse embryos with the
ultimate aim of determining the role of the POMC-related peptides in early development
especially in the CNS. Mouse embryos at gestational days 10.5, 11.5, 12.5 and 14.5 were
analyzed for POMC-derived peptides by SDS-PAGE, HPLC and radioimmunoassay using
antisera specific for various regions of the prohormone. At embryonic day 10.5 (E 10.5) the …