Aminoglycoside ototoxicity
MD Rizzi, K Hirose - Current opinion in otolaryngology & head …, 2007 - journals.lww.com
MD Rizzi, K Hirose
Current opinion in otolaryngology & head and neck surgery, 2007•journals.lww.comThere are currently no recommendations for pretreatment or posttreatment therapies to
attenuate ototoxicity associated with aminoglycoside antibiotics. Our understanding of the
mechanisms of ototoxicity has improved and apoptotic pathways are clearly responsible for
hair cell demise. Further studies are necessary before significant improvement in hearing
outcome can be expected after use of ototoxic antibiotics.
attenuate ototoxicity associated with aminoglycoside antibiotics. Our understanding of the
mechanisms of ototoxicity has improved and apoptotic pathways are clearly responsible for
hair cell demise. Further studies are necessary before significant improvement in hearing
outcome can be expected after use of ototoxic antibiotics.
Summary
There are currently no recommendations for pretreatment or posttreatment therapies to attenuate ototoxicity associated with aminoglycoside antibiotics. Our understanding of the mechanisms of ototoxicity has improved and apoptotic pathways are clearly responsible for hair cell demise. Further studies are necessary before significant improvement in hearing outcome can be expected after use of ototoxic antibiotics.
Lippincott Williams & Wilkins