Histone modifications in transcriptional regulation
SL Berger - Current opinion in genetics & development, 2002 - Elsevier
Current opinion in genetics & development, 2002•Elsevier
Covalent modifications of the amino termini of the core histones in nucleosomes have
important roles in gene regulation. Research in the past two years reveals these
modifications to consist of phosphorylation, methylation and ubiquitination, in addition to the
better-characterized acetylation. This multiplicity of modifications, and their occurrence in
patterns and dependent sequences, argues persuasively for the existence of a histone code.
important roles in gene regulation. Research in the past two years reveals these
modifications to consist of phosphorylation, methylation and ubiquitination, in addition to the
better-characterized acetylation. This multiplicity of modifications, and their occurrence in
patterns and dependent sequences, argues persuasively for the existence of a histone code.
Covalent modifications of the amino termini of the core histones in nucleosomes have important roles in gene regulation. Research in the past two years reveals these modifications to consist of phosphorylation, methylation and ubiquitination, in addition to the better-characterized acetylation. This multiplicity of modifications, and their occurrence in patterns and dependent sequences, argues persuasively for the existence of a histone code.
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