Background: The Brugada syndrome is a familial arrhythmia that manifests as ventricular tachycardia or ventricular fibrillation. It leads to syncope or sudden death in young adults with structurally normal hearts. Episodes are preceded by ST-segment elevation in precordial leads V 1 and V 2. An estimated 18% to 30% of patients carry loss-of-function mutations in SCN5A, the gene that encodes the cardiac sodium channel (1). Anecdotes suggest that fever may be associated with cardiac arrest and preceding electrocardiographic (ECG) changes (Figure)(2, 3).