The chemokine CXCL10 modulates excitatory activity and intracellular calcium signaling in cultured hippocampal neurons
TE Nelson, DL Gruol - Journal of neuroimmunology, 2004 - Elsevier
In this study, we provide evidence for direct modulatory effects of the chemokine, CXCL10,
on the physiology of hippocampal neurons maintained in primary culture. CXCL10 elicited a
rise in intracellular Ca2+ and enhanced both spontaneous and evoked electrical activity of
hippocampal neurons. CXCL10-induced elevations in intracellular Ca2+ were associated
with an increase in neuronal firing and an alteration in the relationship between the evoked
Ca2+ signal and neuronal activity. The effects of CXCL10 were not accompanied by a shift …
on the physiology of hippocampal neurons maintained in primary culture. CXCL10 elicited a
rise in intracellular Ca2+ and enhanced both spontaneous and evoked electrical activity of
hippocampal neurons. CXCL10-induced elevations in intracellular Ca2+ were associated
with an increase in neuronal firing and an alteration in the relationship between the evoked
Ca2+ signal and neuronal activity. The effects of CXCL10 were not accompanied by a shift …