[HTML][HTML] Emerging regulation and functions of autophagy

P Boya, F Reggiori, P Codogno - Nature cell biology, 2013 - nature.com
Nature cell biology, 2013nature.com
Autophagy maintains cell, tissue and organism homeostasis through degradation. Complex
post-translational modulation of the Atg (autophagy-related) proteins adds additional entry
points for crosstalk with other cellular processes and helps define cell-type-specific
regulations of autophagy. Beyond the simplistic view of a process exclusively dedicated to
the turnover of cellular components, recent data have uncovered unexpected functions for
autophagy and the autophagy-related genes, such as regulation of metabolism, membrane …
Abstract
Autophagy maintains cell, tissue and organism homeostasis through degradation. Complex post-translational modulation of the Atg (autophagy-related) proteins adds additional entry points for crosstalk with other cellular processes and helps define cell-type-specific regulations of autophagy. Beyond the simplistic view of a process exclusively dedicated to the turnover of cellular components, recent data have uncovered unexpected functions for autophagy and the autophagy-related genes, such as regulation of metabolism, membrane transport and modulation of host defenses — indicating the novel frontiers lying ahead.
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