[HTML][HTML] Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy
K Sugawara, NN Suzuki, Y Fujioka… - Journal of Biological …, 2005 - ASBMB
Reversible modification of Atg8 with phosphatidylethanolamine is crucial for autophagy, the
bulk degradation system conserved in eukaryotic cells. Atg4 is a novel cysteine protease
that processes and deconjugates Atg8. Herein, we report the crystal structure of human
Atg4B (HsAtg4B) at 1.9-Å resolution. Despite no obvious sequence homology with known
proteases, the structure of HsAtg4B shows a classical papain-like fold. In addition to the
papain fold region, HsAtg4B has a small α/β-fold domain. This domain is thought to be the …
bulk degradation system conserved in eukaryotic cells. Atg4 is a novel cysteine protease
that processes and deconjugates Atg8. Herein, we report the crystal structure of human
Atg4B (HsAtg4B) at 1.9-Å resolution. Despite no obvious sequence homology with known
proteases, the structure of HsAtg4B shows a classical papain-like fold. In addition to the
papain fold region, HsAtg4B has a small α/β-fold domain. This domain is thought to be the …