[HTML][HTML] Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates
The Atg4 cysteine proteases are required for processing Atg8 for the latter to be conjugated
to phosphatidylethanolamine on autophagosomal membranes, a key step in
autophagosome biogenesis. Notably, whereas there are only one atg4 and one atg8 gene
in the yeast, the mammals have four Atg4 homologues and six Atg8 homologues. The Atg8
homologues seem to play different roles in autophagosome biogenesis, and previous
studies had indicated that they could be differentially processed by Atg4 homologues. The …
to phosphatidylethanolamine on autophagosomal membranes, a key step in
autophagosome biogenesis. Notably, whereas there are only one atg4 and one atg8 gene
in the yeast, the mammals have four Atg4 homologues and six Atg8 homologues. The Atg8
homologues seem to play different roles in autophagosome biogenesis, and previous
studies had indicated that they could be differentially processed by Atg4 homologues. The …