[HTML][HTML] ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs
EA Alemu, T Lamark, KM Torgersen… - Journal of Biological …, 2012 - ASBMB
Autophagy is a lysosome-dependent degradation system conserved among eukaryotes. The
mammalian Atg1 homologues, Unc-51 like kinase (ULK) 1 and 2, are multifunctional
proteins with roles in autophagy, neurite outgrowth, and vesicle transport. The mammalian
ULK complex involved in autophagy consists of ULK1, ULK2, ATG13, FIP200, and ATG101.
We have used pulldown and peptide array overlay assays to study interactions between the
ULK complex and six different ATG8 family proteins. Strikingly, in addition to ULK1 and …
mammalian Atg1 homologues, Unc-51 like kinase (ULK) 1 and 2, are multifunctional
proteins with roles in autophagy, neurite outgrowth, and vesicle transport. The mammalian
ULK complex involved in autophagy consists of ULK1, ULK2, ATG13, FIP200, and ATG101.
We have used pulldown and peptide array overlay assays to study interactions between the
ULK complex and six different ATG8 family proteins. Strikingly, in addition to ULK1 and …