[HTML][HTML] Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway
VB Pillai, NR Sundaresan, G Kim, M Gupta… - Journal of Biological …, 2010 - ASBMB
Since the discovery of NAD-dependent deacetylases, sirtuins, it has been recognized that
maintaining intracellular levels of NAD is crucial for the management of stress response of
cells. Here we show that agonist-induced cardiac hypertrophy is associated with loss of
intracellular levels of NAD, but not exercise-induced physiologic hypertrophy. Exogenous
addition of NAD was capable of maintaining intracellular levels of NAD and blocking the
agonist-induced cardiac hypertrophic response in vitro as well as in vivo. NAD treatment …
maintaining intracellular levels of NAD is crucial for the management of stress response of
cells. Here we show that agonist-induced cardiac hypertrophy is associated with loss of
intracellular levels of NAD, but not exercise-induced physiologic hypertrophy. Exogenous
addition of NAD was capable of maintaining intracellular levels of NAD and blocking the
agonist-induced cardiac hypertrophic response in vitro as well as in vivo. NAD treatment …