[HTML][HTML] Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling

KA Martin, BL Merenick, M Ding, KM Fetalvero… - Journal of biological …, 2007 - ASBMB
The phenotypic plasticity of mature vascular smooth muscle cells (VSMCs) facilitates
angiogenesis and wound healing, but VSCM dedifferentiation also contributes to vascular
pathologies such as intimal hyperplasia. Insulin/insulin-like growth factor I (IGF-I) is unique
among growth factors in promoting VSMC differentiation via preferential activation of
phosphatidylinositol 3-kinase (PI3K) and Akt. We have previously reported that rapamycin
promotes VSMC differentiation by inhibiting the mammalian target of rapamycin (mTOR) …