[HTML][HTML] Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium

M Høyer-Hansen, M Jäättelä - Cell Death & Differentiation, 2007 - nature.com
M Høyer-Hansen, M Jäättelä
Cell Death & Differentiation, 2007nature.com
Eukaryotic cells respond to the accumulation of unfolded proteins in the endoplasmic
reticulum (ER) either by unfolded protein response that leads to an increase in the capacity
of the ER to fold its client proteins or by apoptosis when the function of ER cannot be
restored. Emerging data now indicate that ER stress is also a potent inducer of
macroautophagy, a process whereby eukaryotic cells recycle their macromolecules and
organelles. Depending on the context, autophagy counterbalances ER stress-induced ER …
Abstract
Eukaryotic cells respond to the accumulation of unfolded proteins in the endoplasmic reticulum (ER) either by unfolded protein response that leads to an increase in the capacity of the ER to fold its client proteins or by apoptosis when the function of ER cannot be restored. Emerging data now indicate that ER stress is also a potent inducer of macroautophagy, a process whereby eukaryotic cells recycle their macromolecules and organelles. Depending on the context, autophagy counterbalances ER stress-induced ER expansion, enhances cell survival or commits the cell to non-apoptotic death. Here, we discuss the signaling pathways linking ER stress to autophagy and possibilities for their clinical exploitation.
nature.com