p62: a versatile multitasker takes on cancer
J Moscat, MT Diaz-Meco - Trends in biochemical sciences, 2012 - cell.com
Trends in biochemical sciences, 2012•cell.com
Since its initial discovery as an atypical protein kinase C (PKC)-interacting protein, p62 has
emerged as a crucial molecule in a myriad of cellular functions. This multifunctional role of
p62 is explained by its ability to interact with several key components of various signaling
mechanisms. Not surprisingly, p62 is required for tumor transformation owing to its roles as a
key molecule in nutrient sensing, as a regulator and substrate of autophagy, as an inducer of
oxidative detoxifying proteins, and as a modulator of mitotic transit and genomic stability; all …
emerged as a crucial molecule in a myriad of cellular functions. This multifunctional role of
p62 is explained by its ability to interact with several key components of various signaling
mechanisms. Not surprisingly, p62 is required for tumor transformation owing to its roles as a
key molecule in nutrient sensing, as a regulator and substrate of autophagy, as an inducer of
oxidative detoxifying proteins, and as a modulator of mitotic transit and genomic stability; all …
Since its initial discovery as an atypical protein kinase C (PKC)-interacting protein, p62 has emerged as a crucial molecule in a myriad of cellular functions. This multifunctional role of p62 is explained by its ability to interact with several key components of various signaling mechanisms. Not surprisingly, p62 is required for tumor transformation owing to its roles as a key molecule in nutrient sensing, as a regulator and substrate of autophagy, as an inducer of oxidative detoxifying proteins, and as a modulator of mitotic transit and genomic stability; all crucial events in the control of cell growth and cancer.
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