Resident skin cells in psoriasis: a special look at the pathogenetic functions of keratinocytes
C Albanesi, O De Pità, G Girolomoni - Clinics in dermatology, 2007 - Elsevier
Psoriasis is a chronic inflammatory skin disease characterized by exaggerated keratinocyte
proliferation. Current paradigm indicates that psoriasis is driven by T cell–mediated immune
responses targeting keratinocytes. However, psoriasis cannot be explained solely on the
basis of T-cell activation, and it is likely that intrinsic alterations in epidermal keratinocytes
play a very relevant role in disease expression. In particular, keratinocytes may be important
in initiating, sustaining, and amplifying the inflammatory responses by expressing molecules …
proliferation. Current paradigm indicates that psoriasis is driven by T cell–mediated immune
responses targeting keratinocytes. However, psoriasis cannot be explained solely on the
basis of T-cell activation, and it is likely that intrinsic alterations in epidermal keratinocytes
play a very relevant role in disease expression. In particular, keratinocytes may be important
in initiating, sustaining, and amplifying the inflammatory responses by expressing molecules …