[HTML][HTML] Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2
TG Anthony, BJ McDaniel, RL Byerley… - Journal of Biological …, 2004 - ASBMB
In eukaryotic cells, amino acid depletion reduces translation by a mechanism involving
phosphorylation of eukaryotic initiation factor-2 (eIF2). Herein we describe that mice lacking
the eIF2 kinase, general control nonderepressible 2 (GCN2) fail to alter the phosphorylation
of this initiation factor in liver, and are moribund in response to dietary leucine restriction.
Wild-type (GCN2+/+) and two strains of GCN2 null (GCN2–/–) mice were provided a
nutritionally complete diet or a diet devoid of leucine or glycine for 1 h or 6 days. In wild-type …
phosphorylation of eukaryotic initiation factor-2 (eIF2). Herein we describe that mice lacking
the eIF2 kinase, general control nonderepressible 2 (GCN2) fail to alter the phosphorylation
of this initiation factor in liver, and are moribund in response to dietary leucine restriction.
Wild-type (GCN2+/+) and two strains of GCN2 null (GCN2–/–) mice were provided a
nutritionally complete diet or a diet devoid of leucine or glycine for 1 h or 6 days. In wild-type …