[HTML][HTML] Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma
JA Quinn, SX Jiang, DA Reardon… - Journal of clinical …, 2009 - ncbi.nlm.nih.gov
JA Quinn, SX Jiang, DA Reardon, A Desjardins, JJ Vredenburgh, JN Rich, S Gururangan…
Journal of clinical oncology, 2009•ncbi.nlm.nih.govPurpose This phase II trial was designed to define the role of O 6-benzylguanine (O 6-BG) in
restoring temozolomide sensitivity in patients with recurrent or progressive, temozolomide-
resistant malignant glioma and to evaluate the safety of administering O 6-BG in
combination with temozolomide.
restoring temozolomide sensitivity in patients with recurrent or progressive, temozolomide-
resistant malignant glioma and to evaluate the safety of administering O 6-BG in
combination with temozolomide.
Abstract
Purpose
This phase II trial was designed to define the role of O 6-benzylguanine (O 6-BG) in restoring temozolomide sensitivity in patients with recurrent or progressive, temozolomide-resistant malignant glioma and to evaluate the safety of administering O 6-BG in combination with temozolomide.
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