Vascular remodeling is a common feature of many vasculopathies, including graft
arteriosclerosis (GA). We investigated whether endothelial and smooth muscle cell‐derived
neuropilin‐like protein (ESDN) is a marker of vascular remodeling in GA. Immunostaining of
human coronary arteries demonstrated high levels of ESDN in GA, but not in normal arteries.
In a model of GA, where a segment of human coronary is transplanted into a severe
combined immunodeficient mouse, followed by allogeneic human peripheral blood …