[HTML][HTML] Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and …
T Peled, H Shoham, D Aschengrau, D Yackoubov… - Experimental …, 2012 - Elsevier
Strategies that increase homing to the bone marrow and engraftment efficacy of ex vivo
expended CD34+ cells are expected to enhance their clinical utility. Here we report that
nicotinamide (NAM), a form of vitamin B-3, delayed differentiation and increased
engraftment efficacy of cord blood–derived human CD34+ cells cultured with cytokines. In
the presence of NAM, the fraction of CD34+ CD38− cells increased and the fraction of
differentiated cells (CD14+, CD11b+, and CD11c+) decreased. CD34+ cells cultured with …
expended CD34+ cells are expected to enhance their clinical utility. Here we report that
nicotinamide (NAM), a form of vitamin B-3, delayed differentiation and increased
engraftment efficacy of cord blood–derived human CD34+ cells cultured with cytokines. In
the presence of NAM, the fraction of CD34+ CD38− cells increased and the fraction of
differentiated cells (CD14+, CD11b+, and CD11c+) decreased. CD34+ cells cultured with …