Context Gliomas, particularly glioblastomas, are among the deadliest of human tumors.
Gliomas emerge through the accumulation of recurrent chromosomal alterations, some of
which target yet-to-be-discovered cancer genes. A persistent question concerns the
biological basis for the coselection of these alterations during gliomagenesis. Objectives To
describe a network model of a cooperative genetic landscape in gliomas and to evaluate its
clinical relevance. Design, Setting, and Patients Multidimensional genomic profiles and …