Role of insertion elements and yycFG in the development of decreased susceptibility to vancomycin in Staphylococcus aureus
A Jansen, M Türck, C Szekat, M Nagel, I Clever… - International Journal of …, 2007 - Elsevier
The glycopeptide antibiotic vancomycin acts by binding to the D-alanyl-D-alanine terminus
of the cell wall precursor lipid II in the cytoplasmic membrane. The purpose of this study was
the identification of genes that might be involved in the vancomycin resistance mechanism.
To this end, the expression profiles of two vancomycin intermediately resistant
Staphylococcus aureus (VISA) strains, the clinical isolate S. aureus SA137/93A (Etest:
8μg/ml) and its laboratory mutant S. aureus SA137/93G (Etest: 12μg/ml) were analyzed …
of the cell wall precursor lipid II in the cytoplasmic membrane. The purpose of this study was
the identification of genes that might be involved in the vancomycin resistance mechanism.
To this end, the expression profiles of two vancomycin intermediately resistant
Staphylococcus aureus (VISA) strains, the clinical isolate S. aureus SA137/93A (Etest:
8μg/ml) and its laboratory mutant S. aureus SA137/93G (Etest: 12μg/ml) were analyzed …