Development of glycopeptide-intermediate resistance by Staphylococcus aureus leads to attenuated infectivity in a rat model of endocarditis
PA Majcherczyk, JL Barblan, P Moreillon… - Microbial …, 2008 - Elsevier
Glycopeptide-intermediate resistant Staphylococcus aureus (GISA) are characterized by
multiple changes in the cell wall and an altered expression of global virulence regulators.
We investigated whether GISA are affected in their infectivity in a rat model of experimental
endocarditis. The glycopeptide-susceptible, methicillin-resistant S. aureus M1V2 and its
laboratory-derived GISA M1V16 were examined for their ability to (i) adhere to fibrinogen
and fibronectin in vitro,(ii) persist in the bloodstream after intravenous inoculation,(iii) …
multiple changes in the cell wall and an altered expression of global virulence regulators.
We investigated whether GISA are affected in their infectivity in a rat model of experimental
endocarditis. The glycopeptide-susceptible, methicillin-resistant S. aureus M1V2 and its
laboratory-derived GISA M1V16 were examined for their ability to (i) adhere to fibrinogen
and fibronectin in vitro,(ii) persist in the bloodstream after intravenous inoculation,(iii) …