Comparative effects of germfree and ambient environments on the development of cystic kidney disease in CFWwd mice
AA Werder, MA Amos, AH Nielsen… - The Journal of …, 1984 - translationalres.com
A spontaneously occurring murine renal cystic disease that resembles human adult-onset
polycystic renal disease is described. The disease that develops in CFW wd mice is
characterized by multiple bilateral cysts in the kidneys in all affected animals and hepatic
cysts in approximately 20% of these animals with disease. Occasional thoracic aortic
aneurysms were also observed in animals with cystic disease. The prevalence of the
disease appears to be determined by the degree of exposure to the ambient environment. A …
polycystic renal disease is described. The disease that develops in CFW wd mice is
characterized by multiple bilateral cysts in the kidneys in all affected animals and hepatic
cysts in approximately 20% of these animals with disease. Occasional thoracic aortic
aneurysms were also observed in animals with cystic disease. The prevalence of the
disease appears to be determined by the degree of exposure to the ambient environment. A …
