Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short-and long-term memory
Context Chromosome 1q42 is among several genomic regions showing replicated evidence
of linkage with schizophrenia, but the specific susceptibility mechanisms underlying this
relationship remain to be identified. Objective To examine a series of haplotype blocks of
single-nucleotide polymorphic markers from a segment of 1q42 spanning the disrupted-in-
schizophrenia 1 (DISC1) and translin-associated factor X (TRAX) genes for association with
schizophrenia and several endophenotypic traits thought to be involved in disease …
of linkage with schizophrenia, but the specific susceptibility mechanisms underlying this
relationship remain to be identified. Objective To examine a series of haplotype blocks of
single-nucleotide polymorphic markers from a segment of 1q42 spanning the disrupted-in-
schizophrenia 1 (DISC1) and translin-associated factor X (TRAX) genes for association with
schizophrenia and several endophenotypic traits thought to be involved in disease …