Regulation of the expression of inducible nitric oxide synthase
A Pautz, J Art, S Hahn, S Nowag, C Voss, H Kleinert - Nitric oxide, 2010 - Elsevier
Nitric oxide (NO) generated by the inducible isoform of nitric oxide synthase (iNOS) is
involved in complex immunomodulatory and antitumoral mechanisms and has been
described to have multiple beneficial microbicidal, antiviral and antiparasital effects.
However, dysfunctional induction of iNOS expression seems to be involved in the
pathophysiology of several human diseases. Therefore iNOS has to be regulated very
tightly. Modulation of expression, on both the transcriptional and post-transcriptional level, is …
involved in complex immunomodulatory and antitumoral mechanisms and has been
described to have multiple beneficial microbicidal, antiviral and antiparasital effects.
However, dysfunctional induction of iNOS expression seems to be involved in the
pathophysiology of several human diseases. Therefore iNOS has to be regulated very
tightly. Modulation of expression, on both the transcriptional and post-transcriptional level, is …