SDF-1 stimulates neurite growth on inhibitory CNS myelin
J Opatz, P Küry, N Schiwy, A Järve, V Estrada… - Molecular and Cellular …, 2009 - Elsevier
Impaired axonal regeneration is a common observation after central nervous system (CNS)
injury. The stromal cell-derived factor-1, SDF-1/CXCL12, has previously been shown to
promote axonal growth in the presence of potent chemorepellent molecules known to be
important in nervous system development. Here, we report that treatment with SDF-1α is
sufficient to overcome neurite outgrowth inhibition mediated by CNS myelin towards cultured
postnatal dorsal root ganglion neurons. While we found both cognate SDF-1 receptors …
injury. The stromal cell-derived factor-1, SDF-1/CXCL12, has previously been shown to
promote axonal growth in the presence of potent chemorepellent molecules known to be
important in nervous system development. Here, we report that treatment with SDF-1α is
sufficient to overcome neurite outgrowth inhibition mediated by CNS myelin towards cultured
postnatal dorsal root ganglion neurons. While we found both cognate SDF-1 receptors …
