Changes in breast cancer transcriptional profiles after treatment with the aromatase inhibitor, letrozole
WR Miller, AA Larionov, L Renshaw… - Pharmacogenetics …, 2007 - journals.lww.com
Objective The aim of the study was to identify changes in tumour expression profiling
associated with short-term therapy of breast cancer patients with letrozole. Experimental
design Microarray analysis was performed on RNA extracted from paired tumour core
biopsies taken before and after 14 days of treatment with letrozole (2.5 mg/daily) in 58
patients. Changes in expression profile were identified by three different approaches on the
basis of frequency of changes, magnitude of changes and significance analysis of …
associated with short-term therapy of breast cancer patients with letrozole. Experimental
design Microarray analysis was performed on RNA extracted from paired tumour core
biopsies taken before and after 14 days of treatment with letrozole (2.5 mg/daily) in 58
patients. Changes in expression profile were identified by three different approaches on the
basis of frequency of changes, magnitude of changes and significance analysis of …
